Disrupting cellular memory to overcome drug resistance
G. Harmange, S. J. Morrison, M. F. C. Berkers, C. Cote, M. D. Emert, et al., S. M. Shaffer. Nature Communications, 14(1), 7130 (2023).
Oncology Search & Evaluation • Discovery • Single-Cell Genomics
I am a Principal Scientist at Ipsen, primarily working on the Oncology Search & Evaluation team to identify, evaluate, and execute strategic in-licensing opportunities, while also contributing to internal Discovery programs across the biology and biochemistry teams.
I received my Ph.D. from the University of Pennsylvania for research conducted in the Shaffer Lab, investigating non-genetic mechanisms of targeted therapy resistance in melanoma. My doctoral work coupled wet-lab experimentation with computational analyses, using single-cell RNA sequencing and cellular barcoding to trace transcriptional memory and cell-state plasticity.
Prior to graduate school, I was a Summer Fellow at Flagship Pioneering, focused on biotechnology venture ideation. I received my undergraduate education from Northeastern University, majoring in Biochemistry with a minor in Entrepreneurship. During my undergraduate studies, I conducted research in the Slavov Lab, contributing to the development of single-cell proteomics methodologies (SCoPE-MS), and worked on therapeutic gene-editing biochemistry at Editas Medicine.
G. Harmange, S. J. Morrison, M. F. C. Berkers, C. Cote, M. D. Emert, et al., S. M. Shaffer. Nature Communications, 14(1), 7130 (2023).
B. Budnik, E. Levy, G. Harmange, N. Slavov. Genome Biology, 19(1), 161 (2018).